Ono returned home to live with her parents and was suffering from clinical depression when she was briefly placed into a Japanese mental institution.
Ono's second marriage was annulled on March 1, 1963, because she had neglected to finalize her divorce from Ichiyanagi.
Starvation was rampant in the destruction that followed the Tokyo bombings; the Ono family were forced to beg for food while pulling their belongings with them in a wheelchair.
Ono said it was during this period in her life that she developed her "aggressive" attitude and understanding of "outsider" status when children—who were once well-to-do—taunted her and her brother.
She is known for being the second wife and widow of singer-songwriter John Lennon of the Beatles.
Ono grew up in Tokyo and also spent several formative years in New York City.
She remained in Tokyo throughout World War II and the great fire-bombing of March 9, 1945, during which she was sheltered with other family members in a special bunker in Tokyo's Azabu district, far from the heavy bombing.
Ono later went to the Karuizawa mountain resort with members of her family.
They performed at Tokyo's Sogetsu Hall, with Ono lying atop a piano played by John Cage. In the early years of the marriage, Ono left most of Kyoko's parenting to Cox while she pursued her art full-time, with Cox also managing her publicity.
She received a Golden Lion Award for lifetime achievement from the Venice Biennale in 2009 and the 2012 Oskar Kokoschka Prize, Austria's highest award for applied contemporary art.
As Lennon's widow, Ono works to preserve his legacy.
She also co-founded the group Artists Against Fracking in 2012. The next year, Eisuke was transferred from New York City to Hanoi, and the family returned to Japan.
She has a daughter, Kyoko Chan Cox, from her marriage to Anthony Cox and a son, Sean Taro Ono Lennon, from her marriage to Lennon. Ono was enrolled in Keimei Gakuen, an exclusive Christian primary school run by the Mitsui family.