First-generation antihistamines include diphenhydramine (Benadryl), carbinoxamine (Clistin), clemastine (Tavist), chlorpheniramine (Chlor-Trimeton), and brompheniramine (Dimetane).
However, a 1955 study of "antihistaminic drugs for colds," carried out by the U. Army Medical Corps, reported that "there was no significant difference in the proportion of cures reported by patients receiving oral antihistaminic drugs and those receiving oral placebos.
Fexofenadine is associated with a lower risk of cardiac arrhythmia compared to terfenadine.
However, there is little evidence for any advantage of levocetirizine or desloratadine, compared to cetirizine or loratadine, respectively This page is based on a Wikipedia article written by contributors (read/edit).
Many people have demanding lives and cannot be sneezing and feeling groggy all day.
Therefore, it is wise to keep one of these antihistamine brands available for those emergency days.
In type I hypersensitivity allergic reactions, an allergen (a type of antigen) interacts with and cross-links surface Ig E antibodies on mast cells and basophils.
The reason for their peripheral selectivity is that most of these compounds are zwitterionic at physiological p H (around p H 7.4).
Compounds from this group are often used for motion sickness, vertigo, nausea, and vomiting.
The second-generation H receptors and cholinergic receptors.
These agents also commonly have action at α-adrenergic receptors and/or 5-HT receptors.
This lack of receptor selectivity is the basis of the poor tolerability profile of some of these agents, especially when compared with the second-generation HDiphenhydramine was the prototypical agent in this group.